研究実績

Hashimoto K, Machigashira K, Kubota R, Suehara M, Osame M, Lalkaka J, Singhal BS, Fujisawa J, Yoshida M: Sequence analysis of HTLV-I from HAM/TSP in India. 8th Asian and Oceanian Congress of Neurology. Tokyo, Japan, 1991

Hokezu Y, Izumo S, Maruyama I, Kubota R, Moritoyo T, Osame M: Therapeutic trials in the patients with HAM in our department. 4th Annual Retrovirology Conference. Jamaica, 1991

Kubota R, Fujiyoshi T, Izumo S, Yashiki S, Maruyama I, Osame M, Sonoda S: Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy. 3th International Conference on Human Retrovirology: HTLV. Kumamoto, Japan, 1992

Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M: Highly frequent and random mutations of HTLV-I proviral genome within individuals of HAM/TSP patients and asymptomatic carriers. 1995 Annual meeting sponsored by the Laboratory of Tumor Cell Biology. Maryland, USA, 1995

Levin MC, Lehky T, Bamford R, Kubota R, Xavier A, Soldan S, McFarland, Waldmann T, Jacobson S: Decreased HTLV-I viral load in HAM/TSP patients following treatment with humanized anti-Tac. 8th International Conference on Human Retrovirology: HTLV. Rio De Janeiro, Brazil, 1997

Kubota R, Kawanishi T, Levin MC, Jacobson S: Quantitative PCR for HTLV-I proviral DNA. 8th International Conference on Human Retrovirology: HTLV. Rio De Janeiro, Brazil, 1997

Kubota R, Kawanishi T, Mastubara H, Jacobson S: Demonstration of HTLV-I Tax specific CD8+ cells directly in peripheral blood of HAM/TSP patients by intracellular cytokine detection. 8th International Conference on Human Retrovirology: HTLV. Rio De Janeiro, Brazil, 1997

Umehara F, Izumo S, Moritoyo T, Abe M, Kubota R, Osame M: Immunopathology of HTLV-I-associated myelopathy. 9th International Conference on Human Retrovirology: HTLV. Kagoshima, Japan, 1999

Kubota R, Soldan SS, Martin R, Jacobson S: An altered peptide ligand antagonizes antigen-specific CD8+ CTL in peripheral blood of HAM/TSP patients. 9th International Conference on Human Retrovirology: HTLV. Kagoshima, Japan, 1999

Izumo S, Takenouchi N, Moritoyo T, Kubota R, Osame M: Pathogenesis of HTLV-I-associated inflammatory disorders. 10th International Conference on Human Retrovirology: HTLV. Dublin, Ireland, 2000

Furukawa Y, Kubota R, Tara M, Izumo S, Osame M: Existence of escape mutant in HTLV-I tax during the development of adult T cell leukemia. 10th International Conference on Human Retrovirology: HTLV. Dublin, Ireland, 2000

Kubota R, Furukawa Y, Izumo S, Usuku K, Jacobson S, Osame M: Diversity of HTLV-I-specific CTL and proviral load in patients with HAM. 10th International Conference on Human Retrovirology: HTLV. Dublin, Ireland, 2000

Nagai M, Kubota R, Greten TF, Schneck JP, Jacobson S: Increased differentiated and activated HTLV-I Tax 11-19-specific CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I proviral load. 3rd International Symposium on Neurovirology. San Francisco, USA, 2000

Kubota R, Furukawa Y, Izumo S, Osame M: Mutations in HTLV-I Tax 11-19 epitope and mutant virus-specific T cells in patients with HAM/TSP. 11th International Conference on Human Retrovirology: HTLV. San Francisco, USA, 2003

Nose H, Saito M, Usuku K, Matsuzaki T, Izumo S, Kubota R, Furukawa Y, Arimura K, Osame M. Comparison of clinical symptoms and the odds for predicting HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: application of best-fit logistic regression equation based on the genotype, age, and provirus load. 12th International Conference on Human Retrovirology: HTLV & Related Viruses, Montego Bay, Jamaica, 2005

Singhal BS, Lalkaka JA, Sonoda S, Hashimoto K, Nomoto M, Kubota R, Osame M: Human T-lymphotropic virus type I infections in western India. AIDS. 7: 138-139, 1993.

Ijichi S, Izumo S, Eiraku N, Machigashira K, Kubota R, Nagai M, Ikegami I, Kashio N, Umehara F, Maruyama I, Osame M: An autoagressive process against bystander tissues in HTLV-I-infected individuals: a possible pathomechanism of HAM/TSP. Medical Hypotheses. 41: 542-547, 1993.

Yamagata H, Miki T, Sakoda S, Yamanaka N, Davies J, Shelbourne P, Nakagawa M, Takenaga S, Kubota R, Ogihara T, Johnson K: Detection of premutation in Japanese myotonic dystrophy. Hum Mol Genet. 3: 819-820, 1994.

Orita S, Kobayashi H, Saiga A, Kubota R, Osame M, Igarashi H: A spontaneous point mutation in the Human T-cell leukemia virus type 1 pX gene leads to expression of a novel doubly spliced pX-mRNA that encodes a 25kD, amino-terminal deleted rex protein. DNA Cell Biol. 13: 353-364, 1994.

Umehara F, Nakamura A, Izumo S, Kubota R, Ijichi S, Kashio N, Hashimoto K, Usuku K, Sato E, Osame M: Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I associated myelopathy: A possible mechanism to control viral infection in the central nervous system. J Neuropath Exp Neurol. 53: 617-624, 1994.