研究実績

Izumo S, Xing H, Hayakawa H, Mori K, Arishima S, Kubota R, Gelpi E, Budka H: A role of astrocyte dysfunction in pathogenesis of AIDS encephalopathy. 17th International Congress of Neuropathology. Salzburg, Austria, 2010

Abdullah HM, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Abdelbary NH, Inamori Y, Izumo S: HTLV-I associated polymyositis: a trial to unfold the story. 17th International Congress of Neuropathology. Salzburg, Austria, 2010

Kubota R, Matsuura E, Izumo S: Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic lymphocytes in HTLV-I-associated neurological disease. 17th International Congress of Neuropathology. Salzburg, Austria, 2010

Izumo S. Neuropathology of HTLV-1-associated myelopathy (HAM/TSP): The 50thAnniversary of Japanese Society of Neuropathology. Neuropathology. 2010 Oct;30(5):480-5.

Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T: Intra-and inter-laboratory variability in HTLV-1 proviral load quantification using real-time polymerase chain reaction assays: a multi-center study. Cancer Sci. 101(11): 2361-2367, 2010.

White Y, Yoshimitsu M, Kozako T, Akimoto M, Toji S, Matsushita K, Kubota R, Izumo S, Uozumi K, Shimeno S, Soeda S, Arima N: Increased frequency of HTLV-I Tax specific CD8+ regulatory T-cells in HTLV-I infected individuals. 51th American Society of Hematology Annual Meeting. New Orleans, USA, 2009

Xing HQ, Moritoyo T, Mori K, Sugimoto C, Ono F, Izumo S Expression of proinflammatory cytokines and its relationship with virus infection in the brain of macaques inoculated with macrophage-tropic simian immunodeficiency virus..Neuropathology. 2009 Feb;29(1):13-9.

Ishizu T, Kira J, Osoegawa M, Fukazawa T, Kikuchi S, Fujihara K, Matsui M, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K; Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey. Research Committee of Neuroimmunological Diseases..J Neurol Sci. 2009 May 15;280(1-2):22-8.

Aye MM, Kasai T, Tashiro Y, Xing HQ, Shirahama H, Mitsuda M, Suetsugu T, Tanaka K, Osame M, Izumo S. CD8 positive T-cell infiltration in the dentate nucleus of paraneoplasticcerebellar degeneration. J Neuroimmunol. 2009 Mar 31;208(1-2):136-40.

Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, Hasegawa D, Izumi T, Fujita H, Aratani S, Fujii R, Yagishita N, Kamijuku H, Kanekura T, Seino KI, Nishioka K, Nakajima T, Yamano Y: Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders. Blood. 114(15):3208-3215, 2009.

Xing HQ, Hayakawa H, Izumo K, Kubota R, Gelpi E, Budka H, Izumo S: In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases. Neuropathology. 29(4): 433-442, 2009.

Xing HQ, Hayakawa H, Gelpi E, Kubota R, Budka H, Izumo S: Reduced expression of excitatory amino acid transporter 2 and diffuse microglial activation in the cerebral cortex in AIDS cases with or without HIV encephalitis. J Neuropath Exp Neurol. 68(2):199-209, 2009.

Saito M, Usuku K, Arimura K, Izumo S, Osame M, Ohara Y.Increased frequency of CD4+T cells expressing fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease. J Neurol Sci. 2008 Mar 15;266(1-2):13-9.

Yukitake M, Sueoka E, Sueoka-Aragane N, Sato A, Ohashi H, Yakushiji Y, Saito M, Osame M, Izumo S, Kuroda Y.Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol. 2008 Apr;14(2):130-5.

Sabouri AH, Usuku K, Hayashi D, Izumo S, Ohara Y, Osame M, Saito M.Blood. Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease. 2008 Sep 15;112(6):2411-20.

Xing HQ, Mori K, Sugimoto C, Ono F, Izumo K, Kuboda R, Izumo S: Impaired astrocytes and diffuse activation of microglia in the cerebral cortex in simian immunodeficiency virus-infected macaque without simian immunodeficiency virus encephalitis. J Neuropath Exp Neurol. 67(6):600-611, 2008.

Hayashi D, Kubota R, Takenouchi N, Tanaka Y, Hirano R, Takashima H, Osame M, Izumo S, Arimura K: Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy. J Neuroimmunol. 200(1-2): 115-124, 2008.

Matsuura E, Umehara F, Nose H, Higuchi I, Matsuoka E, Izumi K, Kubota R, Saito M, Izumo S, Arimura K, Osame M: Inclusion body myositis associated with human T-lymphotropic virus-type I infection: eleven patients from an endemic area in Japan. J Neuropath Exp Neurol. 67(1):41-49, 2008.

Xing HQ, Kubota R, Hayakawa H, Izumo S: Role of glial cells in central nervous system injury of human retroviral infection. 13th International Conference on Human Retrovirology: HTLV & Related Viruses, Hakone, Japan, 2007

Nose H, Usuku K, Kubota R, Izumo S, Arimura K, Bangham C, Osame M, Saito M: In vivo selection of human T cell lymphotropic virus type-1-specific CD4+ cells by disease susceptive class II allele and immunodominant peptide complex in HTLV-I-associated neurological disease. 13th International Conference on Human Retrovirology: HTLV & Related Viruses, Hakone, Japan, 2007