研究実績

Kodama D, Izumo K, Kubota R, Matsuzaki T, Takashima H, Izumo S: Characterization of glycans of CD4+T cells in HAM/TSP. 16th International Conference on Human Retrovirology: HTLV & Related Viruses, Montreal, Canada, 2013

Kubota R, Takashima H, Izumo S: Impaired T cell receptor signaling in HTLV-1-infected CD4+ cells from HAM/TSP patients. 16th International Conference on Human Retrovirology: HTLV & Related Viruses, Montreal, Canada, 2013

Yuan J, Matsuura E, Higuchi Y, Hashiguchi A, Nakamura T, Nozuma S, Sakiyama Y, Yoshimura A, Izumo S, Takashima H. Hereditary sensory and autonomic neuropathy type IID caused by an SCN9A mutation. Neurology. 80(18):1641-9, 2013

Sato T, Coler-Reilly A, Utsunomiya A, Araya N, Yagishita N, Ando H, Yamauchi, J, Inoue E, Ueno T, Hasegawa Y, Nishioka K, Nakajima T, Jacobson S, Izumo S, Yamano Y. CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis. PLoS Negl Trop Dis. 7(10):e2479, 2013

Saito M, Tanaka R, Arishima S, Matsuzaki T, Ishihara S, Tokashiki T, Ohya Y, Takashima H, Umehara F, Izumo S, Tanaka Y.Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology. 10:51, 2013.

Matsuura E, Watanabe O, Takashima H, Kubota R, Izumo S: HTLV-1-specific cytotoxic T cell migration in the cerebrum of the patients with HAM/TSP. 13th Asian Oceanian Congress of Neurology. Melbourne, Austria, 2012

Kawabata T, Higashimoto I, Takashima H, Izumo S, Kubota R: Human T-lymphotropic virus type I (HTLV-I)-specific CD8+ cells accumulate in the lungs of patients infected with HTLV-I with pulmonary involvement. J Med Virol. 84(7): 1120-1127, 2012.

Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S: Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic T lymphocytes in HTLV-I-associated neurological disease. 63th American Academy of Neurology Annual Meeting. Hawaii, 2011

Kodama D, Kubota R, Izumo S. Pathway analysis of HAM/TSP. 25th Symposium of the International Association for Comparative Reseach on Leukemia and Related Diseases, Tokyo, Japan, 2011

Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S: Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic lymphocytes in HTLV-I-associated neurological disease. 15th International Conference on Human Retrovirology: HTLV & Related Viruses, Leuven, Belgium, 2011

Kodama D, Kubota R, Izumo S: Gene expression and glycan profiling of CD4+ T cells in HAM/TSP. 15th International Conference on Human Retrovirology: HTLV & Related Viruses, Leuven, Belgium, 2011

Abdullah HM, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Abdelbary NH, Inamori Y, Takashima H, Izumo S: Histopathologic differences between human T-lymphotropic virus type 1 (HTLV-1)-positive and HTLV-1-negative polymyositis. 15th International Conference on Human Retrovirology: HTLV & Related Viruses, Leuven, Belgium, 2011

Matsuzaki T, Kodama T, Kubota R, Izumo S: Recent epidemiologic trends of HAM/TSP in Japan. 15th International Conference on Human Retrovirology: HTLV & Related Viruses, Leuven, Belgium, 2011

Kubota R. Takenouchi N, Matsuzaki T, Takashima H, Izumo S: HLA-A24-restricted HTLV-I-specific CTL response reduces the HTLV-I proviral load but the HLA increases the risk of HAM/TSP. 15th International Conference on Human Retrovirology: HTLV & Related Viruses, Leuven, Belgium, 2011

Abdelbary NH, Abdullah HM, Matsuzaki T, Hayashi D, Tanaka Y, Takashima H, Izumo S, Kubota R: Reduced Tim-3 expression on HTLV-I Tax-specific cytotoxic T lymphocytes in HTLV-I infection. 15th International Conference on Human Retrovirology: HTLV & Related Viruses, Leuven, Belgium, 2011

Fujimura M, Usuki F, Kawamura M, Izumo S. Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure. Toxicol Appl Pharmacol. 2011 Jan 1;250(1):1-9.

Kozako T, Yoshimitsu M, Akimoto M, White Y, Matsushita K, Soeda S, Shimeno H, Kubota R, Izumo S, Arima N: Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders. Hum Immunol. 72(11):1001-1006, 2011.

Abdullah HM, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Abdelbary NH, Inamori Y, Takashima H, Izumo S: Histopathologic differences between human T-lymphotropic virus type 1 (HTLV-1)-positive and HTLV-1-negative polymyositis. Clin Exp Neuroimmunol. 2: 12-17, 2011.

Abdelbary NH, Abdullah HM, Matsuzaki T, Hayashi D, Tanaka Y, Takashima H, Izumo S, Kubota R: Reduced Tim-3 expression on HTLV-I Tax-specific cytotoxic T lymphocytes in HTLV-I infection. J Infect Dis. 203(7): 948-959, 2011.

Kozako T, Akimoto M, Toji S, White Y, Suzuki S, Arima T, Suruga Y, Matsushita K, Shimeno H, Soeda S, Kubota R, Izumo S, Uozumi K, Arima N: Target epitopes of HTLV-1 recognized by class I MHC-restricted cytotoxic T lymphocytes in HAM/TSP patients and infected patients with autoimmune disorders. J Med Virol. 83(3):501-509, 2011.