研究実績

Matsuura E, Kubota R, Saito M, Suehara T, Matsuzaki K, Arimura K, Osame M, Izumo S : Bystander damage of the central nervous system by HTLV-I specific CTL with target cell infiltration in HAM/TSP. 13th International Conference on Human Retrovirology: HTLV & Related Viruses, Hakone, Japan, 2007

Takenouchi N, Kubota R, Matsuzaki T, Furukawa Y, Izumo S, Arimura K, Osame M: HLA-A*2402 determines a risk of HAM/TSP independently from the HTLV-I proviral load. 13th International Conference on Human Retrovirology: HTLV & Related Viruses, Hakone, Japan, 2007

Yamano Y, Kubota R, Arimura K, Ozaki S, Izumo S, Nishioka K, Osame M, Nakajima T. High expression of CD28 costimulatory molecule and low expression of CTLA4 inhibitory molecule on CD4+CD25+ T cells in HTLV-I associated myelopathy (HAM/TSP). 13th International Conference on Human Retrovirology: HTLV & Related Viruses, Hakone, Japan, 2007

Hayashi D, Kubota R, Nose H, Arimura K, Izumo S, Osame M: Increased CMV-specific CTL associated with decreased expression of Foxp3 in HAM/TSP. 13th International Conference on Human Retrovirology: HTLV & Related Viruses, Hakone, Japan, 2007

Kubota R, Furukawa Y, Arimura K, Osame M, Izumo S: Genetic stability of HTLV-I despite antiviral pressures by cytotoxic T lymphocytes. 13th International Conference on Human Retrovirology: HTLV & Related Viruses, Hakone, Japan, 2007

Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, Choi K, Bhattacharjee MB, Arimura K, Umehara F, Izumo S, Northrop JL, Salih MA, Inoue K, Armstrong DL, Champoux JJ, Takashima H, Boerkoel CF. Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? EMBO J. 26(22):4732-43, 2007

Arimura K, Nakagawa M, Izumo S, Usuku K, Itoyama Y, Kira Safety and efficacy of interferon-alpha in 167 patients with human T-cell lymphotropic virus type 1-associated myelopathy. J, Osame M.J Neurovirol. 2007 Aug;13(4):364-72.

Nose H, Kubota R, Seth NP, Goon PK, Tanaka Y, Izumo S, Usuku K, Ohara Y, Wucherpfennig KW, Bangham CRM, Osame M. Saito M: Ex vivo analysis of human T cell lymphotropic virus type-1 (HTLV-1) specific CD4+ cells using MHC class II tetramer composed of neurological disease susceptive allele and its immunodominant peptide. J Infect Dis. 196, 1761-1772, 2007.

Obama K, Kubota R, Tara M, Furukawa Y. Osame M, Arimura A: Killer cell immunoglobulin-like receptor/3DL2 expression in adult T-cell leukaemia. Br J Haematol. 138, 666-667, 2007.

Kubota R, Hanada K, Furukawa Y, Arimura K, Osame M, Gojobori T, Izumo S: Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs. J Immunol. 178(9), 5966-5972, 2007.

Izumo S, Xing HQ, Kubota R, Hayakawa H, Gelpi E, Budka H: Microglial activation correlated with decreased expression of EAAT-2 in the cerebral cortex of HIV-1 infected patients: a neuroprotective role of microglia in AIDS encephalopathy. 8th International Conference of Neuroimmunology. Nagoya, Japan, 2006

Nose H, Saito M, Sabouri AH, Usuku K, Kubota R, Izumo S, Arimura K, Osame M: In vivo selection of T-cell receptor junctional region sequences by HLA-DRB1*0101 human T-cell lymphotropic virus type 1 (HTLV-1) envelope gp21 peptide complexes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). 8th International Conference of Neuroimmunology. Nagoya, Japan, 2006

Matsuura E, Kubota R, Saito M, Suehara M, Matsuzaki T, Arimura K, Osame M, Izumo S: Visualization of HTLV-I Tax-specific cytotoxic T lymphocytes in the central nervous system of HTLV-I-associated myelopathy. 8th International Conference of Neuroimmunology. Nagoya, Japan, 2006

Hayashi D, Kubota R, Nose H, Arimura K, Izumo S, Osame M: Increased CTL responses to CMV in HAM/TSP: a relation of FOXP3+ regulatory T cells. 8th International Conference of Neuroimmunology. Nagoya, Japan, 2006

Kubota R, Arimura K, Osame M, Izumo S: HTLV-I-specific CTL with high TCR degeneracy efficiently recognize naturally occurring mutant viruses in patients with HAM/TSP. 8th International Conference of Neuroimmunology. Nagoya, Japan, 2006

Nose H, Saito M, Usuku K, Sabouri AH, Matsuzaki T, Kubota R, Eiraku N, Furukawa Y, Izumo S, Arimura K, Osame M: Clinical symptoms and the odds of human T-cell lymphotropic virus type 1-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: Application of best-fit logistic regression equation based on host genotype, age, and provirus load. J Neurovirol. 12(3):171-7, 2006.

Okamoto Y, Takashima H, Higuchi I, Matsuyama W, Suehara M, Nishihira Y, Hashiguchi A, Hirano R, Ng AR, Nakagawa M, Izumo S, Osame M, Arimura K.Molecular mechanism of rigid spine with muscular dystrophy type 1 caused by novel mutations of selenoprotein N gene. Neurogenetics. 2006 Jul;7(3):175-83.

Furukawa Y, Tara M, Izumo S, Arimura K, Osame M.HTLV-I viral escape and host genetic changes in the development of adult T cell leukemia. Int J Cancer. 2006 Jan 15;118(2):381-7.

Nobuhara Y, Usuku K, Saito M, Izumo S, Arimura K, Bangham CR, Osame M.Genetic variability in the extracellular matrix protein as a determinant of risk for developing HTLV-I-associated neurological disease. Immunogenetics. 2006 Jan;57(12):944-52.

Saito M, Nose H, Usuku K, Sabouri AH, Matsuzaki T, Izumo S, Arimura K, Osame M.Flow cytometry evaluation of the T-cell receptor Vbeta repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals: effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

J Neurol Sci. 2006 Jul 15;246(1-2):37-43.