研究実績

Nozuma S, Matsuura E, Matsuzaki T, Kodama D, Kubota R, Izumo S, Takashima H: Effects of Host Restriction Factors and the HTLV-1 Subtype on Susceptibility to HAM/TSP. 18th International Conference on Human Retrovirology: HTLV & Related Viruses, Tokyo, Japan, 2017

Tashiro Y, Matsuura E, Sagara Y, Kubota R, Takashima H: Estimated Number of HTLV-1 Carriers in Kagoshima. 18th International Conference on Human Retrovirology: HTLV & Related Viruses, Tokyo, Japan, 2017

Ushirogawa H, Arishima S, Yasunaga J, Kubota R, Ohshima K, Izumo S, Matsuoka M, Saito M: Establishment of a Novel Small Animal Model for HAM/TSP. 18th International Conference on Human Retrovirology: HTLV & Related Viruses, Tokyo, Japan, 2017

Hasui K, Sato E, Kiwaki S, Mitsuda M, Saito M, Hara H, Kubota R, Izumo S: Probability of Re-circulation of Lymphoma Type Adult T-cell Leukemia (ATL) Cells into Peripheral Blood: An Antigen-Retrieval (AR)- Immunohistochemistry (IHC) of Stem Cell and Neoplastic Features in Lymphoma Type ATL Cells in the Involved Lymph Nodes. 18th International Conference on Human Retrovirology: HTLV & Related Viruses, Tokyo, Japan, 2017

Matsuzaki T, Saito M, Yamano Y, Nagai M, Takashima H, Izumihara T, Yoshitama T, Kubota R: Effect of Biologic Agents on HAM/TSP with Rheumatoid Arthritis. 18th International Conference on Human Retrovirology: HTLV & Related Viruses, Tokyo, Japan, 2017

Kodama D, Matsuzaki T, Takashima H, Kubota R: ER Stress Response Induced by Inhibition of GRP94 or LacNAc synthetase B3GnT2 in CD4+T Cells of HAM/TSP. 18th International Conference on Human Retrovirology: HTLV & Related Viruses, Tokyo, Japan, 2017

Kubota R, Kodama D, Takashima H: Gene Expression Profile of Activated HTLV-1-Infected Cells from HAM/TSP　Patients. 18th International Conference on Human Retrovirology: HTLV & Related Viruses, Tokyo, Japan, 2017

Xing HQ, Zhang Y, Izumo K, Arishima S, Kubota R, Ye X, Xu Q, Mori K, Izumo S: Decrease of aquaporin-4 and excitatory amino acid transporter-2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV-associated neurocognitive disorders. Neuropathology. 37(1):25-34, 2017.

Wang J, Zhang Y, Xu Q, Qiu J, Zheng H, Ye X, Xue Y, Yin Y, Zhang Z, Liu Y, Hao Y, Wei Q, Wang W, Mori K, Izumo S, Kubota R, Shao Y, Xing HQ: Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells. Oncotarget. doi: 10.18632/oncotarget.14993. 2017

Matsuura E, Nozuma S, Tashiro Y, Kubota R, Izumo S, Takashima H. HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. J Neurol Sci. 371:112-116, 2016.

Matsuura E, Nozuma S, Kubota R, Izumo S, Takashima H: Analysis of the association between the sex and disease courses of 132 consequent patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). 17th International Conference on Human Retrovirology: HTLV & Related Viruses, Martinique, France, 2015

Kodama D, Kubota R, Matsuzaki T, Takashima H, Izumo S: HTLV-1 infected CD4+ T cells of HAM/TSP patients are susceptible to tunicamycin-induced endoplasmic reticulum stress. 17th International Conference on Human Retrovirology: HTLV & Related Viruses, Martinique, France, 2015

Sakiyama Y, Kanda N, Higuchi Y, Yoshimura M, Wakaguri H, Takata Y, Watanabe O, Yuan J, Tashiro Y, Saigo R, Nozuma S,Yoshimura A, Arishima S, Ikeda K, Shinohara K, Arata H, Michizono K, Higashi K, Hashiguchi A, Okamoto Y, Hirano R, Shiraishi T,Matsuura E, Okubo R, Higuchi I, Goto M, Hirano H, Sano A, Iwasaki T, Matsuda F, Izumo S, Takashima H.New type of encephalomyelitis responsive to trimethoprim/sulfamethoxazole treatment in Japan. Neurol Neuroimmunol Neuroinflamm. 2(5):e143, 2015

Kuramitsu M, Okuma K, Yamochi T, Sato T, Sasaki D, Hasegawa H, Umeki K, Kubota R, et al. Standardization of Quantitative PCR for Human T-cell Leukemia Virus Type 1 in Japan: A Collaborative Study. J Clin Microbiol. 53(11):3485-91, 2015

Matsuura E, Yoshimura A, Nozuma S, Higuchi I, Kubota R, Takashima H: Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). BMC Neurol. 15:18, 2015.

Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S: Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. J Neuropath Exp Neurol.74(1): 2-14, 2015.

Nozuma S, Matsuura E, Matsuzaki T, Watanabe O, Kubota R, Izumo S, Takashima H: Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. PLoS One. 9(5):e86144, 2014.

Matsuzaki T, Kubota R, Takashima H, Izumo S: Early diagnosis of HTLV-1-associated myelopathy (HAM/TSP) in HTLV-1 carrier clinic. 16th International Conference on Human Retrovirology: HTLV & Related Viruses, Montreal, Canada, 2013

Matsuura E, Nozuma S, Matsuzaki T, Watanabe O, Kubota R, Izumo S, Takashima H: Inflammation with HTLV-1-specific CTLs occurs in the spinal cord of HTLV-1 carriers and the brain of the patients with HAM/TSP. 16th International Conference on Human Retrovirology: HTLV & Related Viruses, Montreal, Canada, 2013

Nozuma S, Matsuura E, Matsuzaki T , Watanabe O, Kubota R, Izumo S, Takashima H: Clinical features of familial HTLV-I-associated myelopathy/tropical spastic paraparesis. 16th International Conference on Human Retrovirology: HTLV & Related Viruses, Montreal, Canada, 2013