研究実績

Takenouchi N, Yamano Y, Usuku K, Osame M, Izumo S.Usefulness of proviral load measurement for monitoring of disease activity in individual patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol. 2003 Feb;9(1):29-35.

Boerkoel CF, Takashima H, Nakagawa M, Izumo S, Armstrong D, Butler I, Mancias P, Papasozomenos SC, Stern LZ, Lupski JR.CMT4A: identification of a Hispanic GDAP1 founder mutation. Ann Neurol. 2003 Mar;53(3):400-5.

Sugimoto C, Tadakuma K, Otani I, Moritoyo T, Akari H, Ono F, Yoshikawa Y, Sata T, Izumo S, Mori K.nef gene is required for robust productive infection by simian immunodeficiency virus of T-cell-rich paracortex in lymph nodes. J Virol. 2003 Apr;77(7):4169-80.

Furukawa Y, Saito M, Matsumoto W, Usuku K, Tanaka Y, Izumo S, Osame M. Different cytokine production in tax-expressing cells between patients with human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis and asymptomatic HTLV-I carriers. J Infect Dis. 2003 Apr 1;187(7):1116-25.

Isashiki Y, Sonoda S, Izumo S, Sakamoto T, Tachikui H, Inoue I.Phylogenetic assessment of the mitochondrial DNA displacement loop haplotype in Japanese patients with Leber’s hereditary optic neuropathy harboring the mitochondrial DNA G11778A mutation. Ophthalmic Res. 2003 Jul-Aug;35(4):224-31.

Furukawa Y, Kubota R, Eiraku N, Nakagawa M, Usuku K, Izumo S, Osame M: Human T-cell lymphotropic virus type I (HTLV-I)-related clinical and laboratory findings for HTLV-I-infected blood donors. J Acquir Immune Defic Syndr 32(3): 328-334, 2003.

Kubota R, Furukawa Y, Izumo S, Usuku K, Osame M: Degenerate specificity of HTLV-I-specific CD8+ T cells during viral replication in patients with HTLV-I-associated myelopathy (HAM/TSP). Blood 101(8): 3074-3081, 2003.

Saito M, Usuku K, Nobuhara Y, Matsumoto W, Kodama D, Sabouri AH, Izumo S, Arimura K, Osame M.Serum concentration and genetic polymorphism in the 5′-untraslated region of VEGF is not associated with susceptibility to HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals. J Neurol Sci. 2004 Apr 15;219(1-2):157-61.

Sakakima H, Yoshida Y, Muramatsu T, Yone K, Goto M, Ijiri K, Izumo S.Traumatic injury-induced midkine expression in the adult rat spinal cord during the early stage. J Neurotrauma. 2004 Apr;21(4):471-7.

Sabouri AH, Saito M, Lloyd AL, Vine AM, Witkover AW, Furukawa Y, Izumo S, Arimura K, Marshall SE, Usuku K, Bangham CR, Osame M.Polymorphism in the interleukin-10 promoter affects both provirus load and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Infect Dis. 2004 Oct 1;190(7):1279-85.

Furukawa Y, Usuku K, Izumo S, Osame M.Human T cell lymphotropic virus type I (HTLV-I) p12I is dispensable for HTLV-I transmission and maintenance of infection in vivo. AIDS Res Hum Retroviruses. 2004 Oct;20(10):1092-9.

Sabouri AH, Saito M, Usuku K, Bajestan SN, Mahmoudi M, Forughipour M, Sabouri Z, Abbaspour Z, Goharjoo ME, Khayami E, Hasani A, Izumo S, Arimura K, Farid R, Osame M.Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. J Gen Virol. 2005 Mar;86(Pt 3):773-81.

Kodama D, Saito M, Matsumoto W, Sabouri AH, Izumo S, Arimura K, Usuku K, Bangham CR, Osame M. Longer dinucleotide repeat polymorphism in matrix metalloproteinase-9 (MMP-9) gene promoter which correlates with higher HTLV-I Tax mediated transcriptional activity influences the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). J Neuroimmunol. 156(1-2):188-94, 2004.

Saito M, Nakagawa M, Kaseda S, Matsuzaki T, Jonosono M, Eiraku N, Kubota R, Takenouchi N, Nagai M, Furukawa Y, Usuku K, Izumo S, Osame M: Decreased human T lymphotropic virus type I (HTLV-I) provirus load and alteration in T cell phenotype after interferon-alpha therapy for HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis. 189(1): 29-40, 2004.

Saito M, Eiraku N, Usuku K, Nobuhara Y, Matsumoto W, Kodama D, Sabouri AH, Izumo S, Arimura K, Osame M.ApaI polymorphism of vitamin D receptor gene is associated with susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in HTLV-1 infected individuals. J Neurol Sci. 2005 May 15;232(1-2):29-35.

Matsuzaki T, Saito M, Usuku K, Nose H, Izumo S, Arimura K, Osame M.A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. J Neurol Sci. 2005 Oct 15;237(1-2):75-81.