研究実績

Kubota R, Kawanishi T, Matsubara H, Manns A, Jacobson S: HTLV-I-specific IFN-+ CD8+ cells correlate with the proviral load in peripheral blood of infected individuals. J Neuroimmunol. 102: 208-215, 2000.

Kubota R, Nagai M, Kawanishi T, Osame S, Jacobson S: Increased HTLV type 1 tax specific CD8+ cells in HTLV type 1-associated myelopathy/tropical spastic paraparesis: Correlation with HTLV type 1 proviral load. AIDS Res Hum Retrov. 16(16): 1705-1709, 2000.

Miley WJ, Suryanarayana K, Manns A, Kubota R, Jacobson S, Lifson JD, Waters D: Real-time polymerase chain reaction assay for cell-associated HTLV type I DNA viral load. AIDS Res Hum Retrov. 16(7): 665-675, 2000.

Matsuyama W, Kubota R, Hamasaki T, Mizoguchi A, Iwami F, Wakimoto J, Kawabata M, Osame M: Enhanced inhibition of lymphocyte activation by Mycobacterium avium complex in human T lymphotropic virus type I carriers. Thorax 56(5): 394-397, 2001.

Furukawa Y, Kubota R, Tara M, Izumo S, Osame M: Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood. 97(4): 987-993, 2001.

Nagai M, Kubota R, Greten TF, Schneck JP, Leist TP, Jacobson S: Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. J Infect Dis. 183(2): 197-205, 2001.

Yamano Y, Nagai M, Brennan M, Mora CA, Soldan SS, Tomaru U, Takenouchi N, Izumo S, Osame M, Jacobson S.Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP). Blood. 2002 Jan 1;99(1):88-94.

Umehara F, Itoh K, Michizono K, Abe M, Izumo S, Osame M.Involvement of Fas/Fas ligand system in the spinal cords of HTLV-I-associated myelopathy. Acta Neuropathol. 2002 Apr;103(4):384-90.

Wang X, Miyake H, Okamoto M, Saito M, Fujisawa J, Tanaka Y, Izumo S, Baba M.Inhibition of the tax-dependent human T-lymphotropic virus type I replication in persistently infected cells by the fluoroquinolone derivative k-37. Mol Pharmacol. 2002 Jun;61(6):1359-65.

Tuvdendorj D, Isashiki Y, Ohba N, Sonoda S, Izumo S.Two Japanese patients with mutations in the XLRS1 gene. Retina. 2002 Jun;22(3):354-7.

Marin O, Hasui K, Remondegui C, Sato E, Aye MM, Takenouchi N, Izumo S, Tajima K.Adult T-cell leukemia/lymphoma in Jujuy, north-west Argentina. Pathol Int. 2002 May-Jun;52(5-6):348-57.

Vine AM, Witkover AD, Lloyd AL, Jeffery KJ, Siddiqui A, Marshall SE, Bunce M, Eiraku N, Izumo S, Usuku K, Osame M, Bangham CR.Polygenic control of human T lymphotropic virus type I (HTLV-I) provirus load and the risk of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis. 2002 Oct 1;186(7):932-9.

Nagai M, Utsunomiya T, Takenouchi N, Izumo S, Osame M.Failure to detect HTLV type 1 DNA from HTLV type 1-seronegative patients with chronic progressive spastic paraparesis in Kagoshima. AIDS Res Hum Retroviruses. 2002 Sep 20;18(14):1089-90.

Saito M, Higuchi I, Saito A, Izumo S, Usuku K, Bangham CR, Osame M.Molecular analysis of T cell clonotypes in muscle-infiltrating lymphocytes from patients with human T lymphotropic virus type 1 polymyositis. J Infect Dis. 2002 Nov 1;186(9):1231-41.

Hasui K, Takatsuka T, Sakamoto R, Su L, Matsushita S, Tsuyama S, Izumo S, Murata F Improvement of supersensitive immunohistochemistry with an autostainer: a simplified catalysed signal amplification system..Histochem J. 2002 May;34(5):215-22.

Kubota R, Soldan SS, Martin R, Jacobson S: Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient. J Neurovirol. 8(1): 53-57, 2002.

Matsuyama W, Kubota R, Hashiguchi T, Momi H, Kawabata M, Nakagawa M, Arimura K, Osame M: Purified protein derivative of tuberculin upregulates the expression of vascular endothelial growth factor in T lymphocytes in vitro. Immunology 106(1): 96-101, 2002.

Xing HQ, Moritoyo T, Mori K, Tadakuma K, Sugimoto C, Ono F, Hayakawa H, Izumo S.Simian immunodeficiency virus encephalitis in the white matter and degeneration of the cerebral cortex occur independently in simian immunodeficiency virus-infected monkey. J Neurovirol. 2003 Aug;9(4):508-18.

Hasui K, Takatsuka T, Sakamoto R, Matsushita S, Tsuyama S, Izumo S, Murata F.Double autoimmunostaining with glycine treatment. J Histochem Cytochem. 2003 Sep;51(9):1169-76.

Arisato T, Okubo R, Arata H, Abe K, Fukada K, Sakoda S, Shimizu A, Qin XH, Izumo S, Osame M, Nakagawa M.Clinical and pathological studies of familial amyotrophic lateral sclerosis (FALS) with SOD1 H46R mutation in large Japanese families. Acta Neuropathol. 2003 Dec;106(6):561-8.