研究実績

Kubota R, Umehara F, Izumo S, Ijichi S, Matsumuro K, Yashiki S, Fujiyoshi T, Sonoda S, Osame M: HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy. J Neuroimmunol. 53: 23-29, 1994.

Maroushek SR, Osame M, Izumo S, Kubota R, Sato E, Bartholomew C, Haase AT: Sequence analysis of human T cell lymphotropic virus type I (HTLV-I) env genes amplified from central nervous system tissues of patients with HTLV-I-associated myelopathy or leukemia. Microb Pathog 19:317-333, 1995.

Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M: Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients but is not specifically associated with the central nervous system lesions. J Neurovirol. 1: 286-294, 1995.

Furukawa Y, Osame M, Kubota R, Tara M, Yoshida M: Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells. Blood 85: 1865-1870, 1995.

Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M: Mutation rates in LTR of HTLV-I in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence. J Neurovirol. 2: 330-335, 1996.

Takashima H, Nakagawa M, Nakahara K, Suehara M, Matsuzaki T, Higuchi I, Higa H, Arimura K, Iwamasa T, Izumo S, Osame M. A new type of hereditary motor and sensory neuropathy linked to chromosome 3. Ann Neurol. 41(6):771-80, 1997

Biddison WE, Kubota R, Kawanishi T, Taub DD, Cruikshank WW, Center DM, Connor EW, Utz U, Jacobson S: Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. J Immunol. 159: 2018-2025, 1997.

Umehara F, Kore-eda Y, Arime T, Kubota R, Arimura K, Osame M: Chronic sensory ataxic neuropathy and ophthalmoplegia with oculomotor nerve hypertrophy associated with IgM antibodies against gangliosides containing disialosyl groups. J Neurol Neurosurg Psychiatry 62: 673-674, 1997.

Saiga A, Orita S, Ninoura-Tada N, Maeda M, Aono Y, Asakawa M, Nakahara K, Kubota R, Osame M, Igarashi H: cis-Acting inhibitory elements within the pol-env region of human T-cell leukemia virus type 1 possibly involved in viral persistence. J Virol. 71: 4485-4494, 1997.

Nagai M, Usuku K, Matsumoto W, Kodama D, Takenouchi N, Moritoyo T, Hashiguchi S, Ichinose M, Bangham CR, Izumo S, Osame M.Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP.J Neurovirol. 4(6):586-93, 1998

Lehky TJ, Levin MC, Kubota R, Bamford RN, Flerlage AN, Soldan SS, Leist TP, Xavier A, White JD, Brown M, Fleisher TA, Top LE, Light S, McFarland HF, Waldman TA, Jacobson S: Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HAM/TSP patients treated with humanized anti-Tac. Ann Neurol.44: 942-947, 1998.

Shields MJ, Kubota R, Hodgson W, Jacobson S, Biddison WE, Ribaudo RK: The effect of human beta2-microglobulin on major histocompatibility complex I peptide loading and the engineering of a high affinity variant. Implications for peptide-based vaccines. J Bio Chem. 273: 28010-28018, 1998.

Greten TF, Slansky JE, Kubota R, Soldan SS, Jaffee EM, Leist TP, Pardoll DM, Jacobson S, Schneck JP: Direct visualization of antigen-specific T lymphocytes: HTLV-I Tax11-19 specific CD8+ T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Proc Natl Acad Sci USA. 95: 7568-7573, 1998.

Takashima H, Nakagawa M, Kanzaki A, Yawata Y, Horikiri T, Matsuzaki T, Suehara M, Izumo S, Osame M. Germline mosaicism of MPZ gene in Dejerine-Sottas syndrome (HMSN III) associated with hereditary stomatocytosis. Neuromuscul Disord. 9(4):232-8, 1999

Nakagawa M, Takashima H, Suehara M, Saito M, Saito A, Kanzato N, Matsuzaki T, Hirata K, Izumo S, Terwilliger JD, Osame M. Hereditary motor and sensory neuropathy with proximal dominant involvement: clinical, pathological, and genetic features. Ann N Y Acad Sci. 883:449-52, 1999

Nakagawa M, Suehara M, Saito A, Takashima H, Umehara F, Saito M, Kanzato N, Matsuzaki T, Takenaga S, Sakoda S, Izumo S, Osame M. A novel MPZ gene mutation in dominantly inherited neuropathy with focally folded myelin sheaths. Neurology. 52(6):1271-5, 1999

Kubota R, Kawanishi T, Matsubara H, Manns A, Jacobson S: Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ cells directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients by intracellular cytokine detection. J Immunol. 161: 482-488, 1998. (equal contribution)

Umehara F, Yamaguchi N, Kodama D, Takenaga S, Kiwaki T, Sonoda Y, Arimura Y, Yamada H, Arimura K, Osame M. Polyneuropathy with minifascicle formation in a patient with 46XY mixed gonadal dysgenesis. Acta Neuropathol. 98(3):309-12, 1999.

Abe M, Umehara F, Kubota R, Moritoyo T, Izumo S, Osame M: Activation of macrophages/microglia with the calcium-binding proteins MRP14 and MRP8 is related to the lesional activities in the spinal cord of HTLV-I associated myelopathy. J Neurol. 246: 358-364, 1999.

Kubota R, Soldan SS, Martin R, Jacobson S: An altered peptide ligand antagonizes antigen-specific T cells of patients with human T lymphotropic virus type I-associated neurological disease. J Immunol. 164: 5192-5198, 2000.