研究実績
(2018-2022, Selected)
| 1. Takashita E, Kinoshita N, Yamayoshi S, Sakai-Tagawa Y, Fujisaki S, Ito M, Iwatsuki-Horimoto K, Chiba S, Halfmann P, Nagai H, Saito M, Adachi E, Sullivan D, Pekosz A, Watanabe S, Maeda K, Imai M, Yotsuyanagi H, Mitsuya H, Ohmagari N, Takeda M, Hasegawa H, Kawaoka Y. Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant. N Engl J Med. NEJMc2119407, 2022. |
| 2. Matsuda K, Islam S, Takada T, Tsuchiya K, Yang BTJ, Shin-ichiro Hattori SI, Katsuya H, Kitagawa K, Kim KS, Matsuo M, Sugata K, Delino NS, Gatanaga H, Yoshimura K, Matsushita S, Mitsuya H, Iwami S, Satou Y, and Maeda K. A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro. Cell Rep. Methods 1, 100122, 2021. |
| 3. Yamayoshi S, Yasuhara A, Ito M, Akasaka O, Nakamura M, Nakachi I, Koga M, Mitamura K, Yagi K, Maeda K, Kato H, Nojima M, Pattinson D, Ogura T, Baba R, Fujita K, Nagai H, Yamamoto S, Saito M, Adachi E, Ochi J, Hattori SI, Suzuki T, Miyazato Y, Chiba S, Okuda M, Murakami J, Hamabata T, Iwatsuki-Horimoto K, Nakajima H, Mitsuya H, Omagari N, Sugaya N, Yotsuyanagi H, Kawaoka Y. Antibody titers against SARS-CoV-2 decline, but do not disappear for several months. EClinialMedicine. 32:100734, 2021. |
| 4. Maeda K, Amano M, Uemura Y, Tsuchiya K, Matsushima T, Noda K, Shimizu Y, Fujiwara A, Takamatsu Y, Ichikawa Y, Nishimura H, Kinoshita M, Matsumoto S, Gatanaga H, Yoshimura K, Oka SI, Mikami A, Sugiura W, Sato T, Yoshida T, Shimada S, Mitsuya H. Correlates of Neutralizing/SARS-CoV-2-S1-binding Antibody Response with Adverse Effects and Immune Kinetics in BNT162b2-Vaccinated Individuals. Scientific Reports. 2021. |
| 5. Tanaka A, Yamamoto S, Miyo K, Mizoue T, Maeda K, Sugiura W, Mitsuya H, Sugiyama H, Norio Ohmagari. Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan. Journal of Infection. 82(4):e1-e3, 2021. |
| 6. Maeda K., Higashi-Kuwata N, Kinoshita N, Kutsuna S, Tsuchiya K, Hattori SI, Matsuda K, Takamatsu Y, Gatanaga H, Oka S, Sugiyama H, Ohmagari N, Mitsuya H. Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma. Sci Rep. 11(1):5563, 2021. |
| 7. Noda K, Matsuda K, Yagishita S, Maeda K, Akiyama Y, Terada-Hirashima J, Matsushita H, Iwata S, Yamashita K, Atarashi Y, Watanabe S, Ide N, Yoshida T, Ohmagari N, Mitsuya M, Hamada A. A novel highly quantitative and reproducible assay for the detection of anti-SARS-CoV-2 IgG and IgM antibodies. Sci. Rep. 11(1):5198, 2021. |
| 8. Matsuda K, Takuya Kobayakawa T, Kariya R, Tsuchiya K, Tsuji K, Ishii T, Gatanaga H, Yoshimura K, Okada S, Mitsuya H, Tamamura H, Maeda K. A therapeutic strategy to combat HIV-1 latently infected cells with a combination of latency-reversing agents containing DAG-lactone PKC activators. Front. Microbiol. 12:636276, 2021. |
| 9. Yamamoto S, Maeda K, Matsuda K, Tanaka A, Horii K, Okudera K, Takeuchi JS, Mizoue T, Konishi M, Ozeki M, Sugiyama H, Aoyanagi N, Mitsuya H, Sugiura W, Ohmagari N. COVID-19 breakthrough infection and post-vaccination neutralizing antibody among healthcare workers in a referral hospital in Tokyo: a case-control matching study. Clin Infect Dis. 2021. |
| 10. Yamamoto S, Tanaka A, Kobayashi S, Oshiro Y, Ozeki M, Maeda K, Matsuda K, Miyo K, Mizoue T, Sugiura W, Mitsuya H, Sugiyama H, Ohmagari N. Consistency of the results of rapid serological tests for SARS-CoV-2 among healthcare workers in a large national hospital in Tokyo, Japan. Global Health & Medicine. 3(2):90-94, 2021. |
| 11. Yamamoto S, Tanaka A, Oshiro Y, Ishii M, Ishiwari H, Konishi M, Matsuda K, Ozeki M, Miyo K, Maeda K, Mizoue T, Sugiura W, Mitsuya H, Sugiyama H, Ohmagari N. Seroprevalence of SARS-CoV-2 antibodies in a national hospital and affiliated facility after the second epidemic wave of Japan. Journal of Infection. S0163-4453(21)00259-0, 2021. |
| 12. Terada M, KutsunaS, Saito S, Kinoshita N, Shimanishi Y, Suzuki T, Miyazato Y, Inada M, Nakamoto T, Nomoto H, Ide S, Sato M, Maeda K, Matsunaga A, Satake M, Matsubayashi K, Tsuno H, Kojima M, Kuramistu M, Tezuka K, Ikebe E, Okuma K, Hamaguchi I, Shiratori K, Sato M, Kawakami Y, Inaba K, Igarashi S, Yamauchi R, Matsumura M, Ishimaru K, Cho H, Kuge C, Ishihara M, Gouda M, Tanaka K, Ishizaka Y, Ohmagari N. How we secured a COVID-19 Convalescent Plasma Procurement Scheme in Japan. Transfusion, 10.1111/trf.16541, 2021. |
| 13. Nakajima S, Watashi K, Kato T, Muramatsu M, Wakita T, Tamura N, Hattori SI, Maeda K, Mitsuya H, Yasutake Y, Toyoda T. Biochemical and structural properties of entecavir-resistant hepatitis B virus polymerase with L180M/M204V mutations. J. Virol. 95(16):e0240120, 2021. |
| 14. Imai M, Halfmann PJ, Yamayoshi S, Iwatsuki-Horimoto K, Chiba S, Watanabe T, Nakajima N, Ito M, Kuroda M, Kiso M, Maemura T, Takahashi K, Loeber S, Hatta M, Koga M, Nagai H, Yamamoto S, Saito M, Adachi E, Akasaka O, Nakamura M, Nakachi I, Ogura T, Baba R, Fujita K, Ochi J, Mitamura K, Kato H, Nakajima H, Yagi K, Hattori SI, Maeda K, Suzuki T, Miyazato Y, Valdez R, Gherasim C, Furusawa Y, Okuda M, Ujie M, Lopes TJS, Yasuhara A, Ueki H, Sakai-Tagawa Y, Eisfeld AJ, Baczenas JJ, Baker DA, O’Connor SL, O’Connor DH, Fukushi S, Fujimoto T, Kuroda Y, Gordon A, Maeda K, Ohmagari N, Sugaya N, Yotsuyanagi H, Mitsuya H, Suzuki T, Kawaoka Y. Characterization of a new SARS-CoV-2 variant that emerged in Brazil. Proc Natl Acad Sci U S A. 118(27):e2106535118, 2021. |
| 15. Hayashi Y, Tsuchiya K, Yamamoto M, Nemoto-Sasaki Y, Tanigawa K, Hama K, Tanikawa T, Maeda K, Inoue J-I, and Yamashita A. N-(4-Hydroxyphenyl) retinamide suppresses SARS-CoV-2 spike protein-mediated cell-cell fusion and viral infection in vitro. J. Virol. JVI0080721, 2021. |
| 16. Takamatsu Y, Imai M, Maeda K, Nakajima N, Higashi-Kuwata N, Iwatsuki-Horimoto K, Ito M, Kiso M, Maemura T, Takeda Y, Omata K, Suzuki T, Kawaoka Y, Mitsuya H. Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters. J Virol. JVI0155121, 2021. |
| 17. Yasutake Y, Hattori SI, Tamura N, Matsuda K, Kohgo S, Maeda K, Mitsuya H. Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine. Sci Rep. 10(1):3021, 2020. |
| 18. Hattori SI, Higshi-Kuwata N, Raghavaiah J, Das D, Bulut H, Davis DA, Takamatsu Y, Matsuda K, Takamune N, Kishimoto N, Okamura T, Misumi S, Yarchoan R, Maeda K, Ghosh AK, Mitsuya H.GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection. mBio. 11(4):e01833-20, 2020. |
| 19. Yamayoshi S, Sakai-Tagawa Y, Koga M, Akasaka O, Nakachi I, Koh H, Maeda K, Adachi E, Saito M, Nagai H, Ikeuchi K, Ogura T, Baba R, Fujita K, Fukui T, Ito F, Hattori SI, Yamamoto K, Nakamoto T, Furusawa Y, Yasuhara A, Ujie M, Yamada S, Ito M, Mitsuya H, Omagari N, Yotsuyanagi H, Iwatsuki-Horimoto K, Imai M, Kawaoka Y. Comparison of rapid antigen tests for COVID-19. Viruses. 12(12):1420, 2020. |
| 20. Nakata H, Maeda K, Das D, Chang SB, Matsuda K, Kalapala Rao KV, Harada S, Yoshimura K, Ghosh AK, and Mitsuya H. Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s. Sci. Rep. 9(1)4828, 2019. |
| 21. Matsuda K, Kobayakawa T, Tsuchiya K, Hattori SI, Nomura W, Gatanaga H, Yoshimura K, Oka S, Endo Y, Tamamura H, Mitsuya H, and Maeda K*. Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C–induced HIV latency reversal. J. Biol. Chem. 294:116-129, 2019. |
| 22. Iwase, S., Miyazato, P., Katsuya, H., Yang Tan, BJ, Ito, J., Islam, SM, Matsuo, M., Takeuchi, H., Ishida, T., Matsuda, K., Maeda, K., and Satou Y. HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus. Sci. Rep. 9(1) :12326, 2019. |
| 23. Maeda, K, Das D., Kobayakawa T., Tamamura H., and Takeuchi, H. Discovery and Development of anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication. Curr. Top Med. Chem. 9(18):1621-1649, 2019. |
| 24. Yasutake Y, Hattori S, Hayashi H, Matsuda K, Tamura N, Maeda K, and Mitsuya H. HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to an anti-HBV inhibitor, entecavir: structural insights into HBV-RT inhibition by entecavir. Sci Rep. 8:1624, 2018. |
| 25. Takamatsu Y, Das D, Kohgo S, Hayashi H, Delino NS, Sarafianos SG, Mitsuya H, and Maeda K. The high genetic barrier of 4ʹ-ethynyl-2-fluoro-2ʹ-deoxyadenosine (EFdA/MK-8591) stems from strong interactions with the active site of drug-resistant HIV-1 reverse transcriptase. Cell Chem. Biol. S2451-9456(18)30266-6, 2018. |
| 26. Hattori SI, Matsuda K, Tsuchiya K, Gatanaga H, Oka S, Yoshimura K, Mitsuya H, and Maeda K. Combination of a latency-reversing agent with a Smac mimetic minimizes secondary HIV-1 infection in vitro. Frontiers in Microbiology. 9:2022, 2018. |
(2001-2017, Selected)
| 1. Maeda K, Yoshimura K, Shibayama S, Habashita H, Tada H, Sagawa K, Miyakawa T, Aoki M, Fukushima D, Mitsuya H. Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5. J Biol Chem. 276: 35194-35200, 2001. |
| 2. Yoshimura K, Kato R, Kavlick MF, Nguyen A, Maroun V, Maeda K, Hussain KA, Ghosh AK, Gulnik SV, Erickson JW, Mitsuya H. UIC-94003: a potent protease inhibitor (PI) that inhibits multi-PI-resistant HIV-1 replication in vitro. J Virol. 76:1349-1358, 2002. |
| 3. Miyakawa T, Obaru K, Maeda K, Harada S, Mitsuya H. Identification of amino acid residues critical for LD78 beta (a variant of human macrophage inflammatory protein-1 alpha) binding to CCR5 and inhibition of R5 HIV-1 replication. J Biol Chem. 277:4649-4655, 2002. |
| 4. Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N. Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multi-drug resistant HIV-1 strains. J Med Chem. 46:1764-1768, 2003. |
| 5. Koh Y, Nakata H, Maeda K, Ogata H, Bilcer G, Devasamudram T, Kincaid JF, Boross P, Wang YF, Tie Y, Volarath P, Gaddis L, Harrison RW, Weber IT, Ghosh AK, Mitsuya H. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother. 47:3123-3129, 2003. |
| 6. Maeda K, Nakata H, Koh Y, Miyakawa T, Ogata H, Takaoka Y, Shibayama S, Sagawa K, Fukushima D, Moravek J, Koyanagi Y, Mitsuya H. A spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 HIV-1 in vitro. J Virol. 78:8654-8662, 2004. |
| 7. Nakata H, Maeda K, Miyakawa T, Shibayama S, Matsuo M, Takaoka Y, Ito M, Koyanagi Y, Mitsuya H. Potent Anti-R5-HIV-1 Effects of a CCR5 Antagonist AK602 in a Novel hu-PBMC-Non-Obase-Diabetic-SCID, IL-2R gamma-Chain-Knocked-Out AIDS Mouse Model. J Virol. 79: 2087-2096, 2005. |
| 8. Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H. Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance. J Med Chem. 49:5252-5261, 2006. |
| 9. Habashita H, Kokubo M, Hamano S, Hamanaka N, Toda M, Shibayama S, Tada H, Sagawa K, Fukushima D, Maeda K, Mitsuya, H. Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists. J Med Chem. 49:4140-52, 2006. |
| 10. Davis DA, Brown CA, Singer KE, Wang V, Kaufman J, Stahl SJ, Wingfield P, Maeda K, Harada S, Yoshimura K, Kosalaraksa P, Mitsuya H, Yarchoan R. Inhibition of HIV-1 replication by a peptide dimerization inhibitor of HIV-1 protease. Antiviral Res. 72: 89-99, 2006. |
| 11. Maeda K, Das D, Ogata-Aoki H, Nakata H, Miyakawa T, Tojo Y, Norman R, Takaoka Y, Ding J, Arnold GF, Arnold E, Mitsuya H. Structural and molecular interactions of CCR5 inhibitors with CCR5. J Biol Chem. 2006, 281:12688-12698, 2006. |
| 12. Maeda K, and Mitsuya H. Development of therapeutics for AIDS: Structure-based molecular targeting. Tuberculosis. 87:S31-34, 2007. |
| 13. Maeda K, Das D, Yin PD, Tsuchiya K, Ogata-Aoki H, Nakata H, Norman R, Hackney L, Takaoka Y, Mitsuya H. Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: Insights to mechanism of allosteric inhibition. J. Mol. Biol. 381:956-974, 2008. |
| 14. Nakata H, Steinberg SM, Koh Y, Maeda K, Takaoka Y, Tamamura H, Fujii N, Mitsuya H. Potent synergistic anti-HIV effects using combinations of a CCR5 inhibitor aplaviroc with other anti-HIV drugs. Antimicrob. Agents. Chemother. 52:2111-2119, 2008. |
| 15. Hamada A, Sissung T, Price D, Danesi R, Chau C, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut B, Figg W. Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in Caucasian patients with androgen-independent prostatic cancer. Clin. Cancer Res. 14:3312-3318, 2008. |
| 16. Aoki M, Venzon DJ, Koh Y, Aoki-Ogata H, Miyakawa T, Yoshimura K, Maeda K, and Mitsuya H. Non-cleavage site gag mutations in amprenavir-resistant human immunodeficiency virus type 1 (HIV-1) predispose HIV-1 to rapid acquisition of amprenavir resistance but delay development of resistance to other protease inhibitors. J. Virol. 83:3059-3068, 2009. |
| 17. Nishizawa R, Nishiyama T, Hisaichi K, Minamoto C, Murota M, Takaoka Y, Nakai H, Tada H, Sagawa K, Shibayama S, Fukushima D, Maeda K, Mitsuya H. Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: A highly potent orally available CCR5 selective antagonist. Bioorg Med Chem. 19:4028-4042, 2011. |
| 18. Maeda K, Das D, Mitsuya H. Development of Antiviral Therapeutics for HIV-1 Infection and AIDS. In “HIV/AIDS in the Post-HAART Era: Manifestations, Treatment & Epidemiology” (ed. John C. Hall, Brian J. Hall and Clay J. Cockerell), Shelton, CT: People’s medical Publishing House – USA. Chapter 40, p 900-937. 2011. |
| 19. Maeda K, Das D, Nakata H, Mitsuya H. CCR5 Inhibitors: Emergence, Success and Challenges. Expert Opin Emerg Drugs.17:135-145, 2012. |
| 20. Yedidi RS, Maeda K, Fyvie WS, Steffey M, Davis DA, Palmer I, Aoki M, Kaufman JD, Stahl SJ, Garimella H, Das D, Wingfield PT, Ghosh AK, Mitsuya H. P2′ benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. Antimicrob Agents Chemother. 57:4920-4927, 2013. |
| 21. Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H. EFdA, a Reverse Transcriptase Inhibitor, Potently Blocks HIV-1 Ex Vivo Infection of Langerhans Cells within Epithelium. J Invest Dermatol. 134:1158-1161, 2014. |
| 22. Daniels SI, Soule EE, Davidoff KS, Bernbaum JG, Hu D, Maeda K, Stahl SJ, Naiman NE, Waheed AA, Freed EO, Wingfield P, Yarchoan R, Davis DA. Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide. FASEB J. 28:106-116, 2014. |
| 23. Maeda K, Desai DV, Aoki M, Nakata H, Kodama EN, Mitsuya H. Delayed emergence of HIV-1 variants resistant to 4′-ethynyl-2-fluoro-2′-deoxyadenosine: comparative sequential passage study with lamivudine, tenofovir, emtricitabine and BMS-986001. Antivir Ther. 19:179-189, 2014. |
| 24. Takamatsu Y, Tanaka Y, Kohgo S, Murakami S, Singh K, Das D, Venzon DJ, Amano M, Kuwata N, Aoki M, Delino NS, Hayashi S, Takahashi S, Sukenaga Y, Haraguchi K, Sarafianos SG, Maeda K*, and Mitsuya H. 4’-Modified nucleoside analogs: potent inhibitors active against entecavir-resistant HBV. Hepatology 62:1024-1036, 2015. |
| 25. Das D, Maeda K, Hayashi Y, Gavande N, Desai DV, Chang SB, Ghosh AK, Mitsuya H. Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV-1 Inhibitors. Antimicrob. Agents Chemother. 59:1895-1904, 2015. |
| 26. Davis DA, Mishra S, Anagho HA, Aisabor, AI, Shrestha P, Wang V, Takamatsu Y, Maeda K, Mitsuya H, Zeldis JB, Yarchoan R. Restoration of immune surface molecules in Kaposi sarcoma-associated herpesvirus infected cells by lenalidomide and pomalidomide. Oncotarget. 8:50342-50358, 2017. |