{"id":71,"date":"2024-03-17T19:04:04","date_gmt":"2024-03-17T10:04:04","guid":{"rendered":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/~bit\/wpo?page_id=71"},"modified":"2024-03-17T19:14:05","modified_gmt":"2024-03-17T10:14:05","slug":"hcv","status":"publish","type":"page","link":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/reserch\/hcv\/","title":{"rendered":"C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9"},"content":{"rendered":"<h1>C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9<\/h1>\n<h2>HCV\u57f9\u990a\u7d30\u80de\u7cfb\u306e\u958b\u767a<\/h2>\n<p>\u6297\u30a6\u30a4\u30eb\u30b9\u5264\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306b\u306f\uff12\u3064\u306e\u3053\u3068\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\uff11\u3064\u76ee\u306f\u3001\u85ac\u5264\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3067\u3001\uff12\u3064\u76ee\u306f\u3001\u85ac\u5264\u306e\u30a2\u30c3\u30bb\u30a4\u306e\u305f\u3081\u306e\u57f9\u990a\u7d30\u80de\u3067\u3059\u3002\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u3064\u3044\u3066\u306f\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u304c\u552f\u4e00\u306eHCV\u611f\u67d3\u304c\u53ef\u80fd\u306a\u30e2\u30c7\u30eb\u52d5\u7269\u3067\u3059\u304c\u3001\u502b\u7406\u7684\u3001\u7d4c\u6e08\u7684\u7406\u7531\u304b\u3089\u73fe\u5728\u3067\u306f\u5b9f\u9a13\u306b\u4f7f\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3002<br \/>HCV\u306f1989\u5e74\u306b\u767a\u898b\u3055\u308c\u3066\u304b\u3089\u3001\u73fe\u5728\u306b\u81f3\u308b\u307e\u3067\u3001HCV\u967d\u6027\u8840\u6e05\u3092\u7d30\u80de\u306b\u611f\u67d3\u3055\u305b\u3066\u3001\u5897\u6b96\u3055\u305b\u308b\u65b9\u6cd5\u3067\u306f\u30a6\u30a4\u30eb\u30b9\u3092\u5206\u96e2\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u306e\u4ee3\u308f\u308a\u306b\u3001\u5316\u5b66\u5408\u6210\u3092\u3057\u305fHCV\u907a\u4f1d\u5b50\u3092\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3057\u3066\u4eba\u5de5\u7684\u306a\u30a6\u30a4\u30eb\u30b9\u3092\u4f5c\u6210\u3059\u308b\u30ea\u30d0\u30fc\u30b9\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u30b9\u6cd5\u306b\u3088\u308a\u30a6\u30a4\u30eb\u30b9\u3092\u5897\u6b96\u3055\u305b\u3066\u5b9f\u9a13\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>1999\u5e74\u306b\u4eba\u5de5\u7684\u306aHCV\u306e\u8907\u88fd\u306e\u307f\u53ef\u80fd\u306a\u30ec\u30d7\u30ea\u30b3\u30f3\u30b7\u30b9\u30c6\u30e0\u304c\u30c9\u30a4\u30c4\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308a\u958b\u767a\u3055\u308c\u307e\u3057\u305f (Lohmann et al. Science 1999)\u30022005\u5e74\u306b\u306f\u3001\u611f\u67d3\u6027\u30a6\u30a4\u30eb\u30b9\u30af\u30ed\u30fc\u30f3\u3092\u7528\u3044\u305fJFH-1\u611f\u67d3\u30b7\u30b9\u30c6\u30e0\u304c\u65e5\u672c\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308a\u958b\u767a\u3055\u308c\u307e\u3057\u305f (Wakita et al. Nature Med, 2005)\u3002\u3053\u306e\uff12\u3064\u306e\u767a\u898b\u306f\u30d6\u30ec\u30fc\u30af\u30b9\u30eb\u30fc\u3068\u306a\u308aHCV\u7814\u7a76\u3092\u767a\u5c55\u3055\u305b\u3001\u73fe\u5728\u306e\u65b0\u85ac\u958b\u767a\u306b\u81f3\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\u3082\u3046\uff11\u3064\u3001\u91cd\u8981\u306a\u767a\u898b\u3068\u3057\u3066\u5fd8\u308c\u3066\u306a\u3089\u306a\u3044\u306e\u304c\u30011982\u5e74\u306e\u30d2\u30c8\u809d\u304c\u3093\u7d30\u80de\u682aHuH-7\u306e\u6a39\u7acb\u3067\u3059\uff08Nakabayashi et al. Cancer Res, 1982\uff09\u3002HCV\u306f\u975e\u5e38\u306b\u7e4a\u7d30\u306a\u30a6\u30a4\u30eb\u30b9\u3067HuH-7\u7d30\u80de\u682a\u4ee5\u5916\u3067\u306f\u52b9\u7387\u826f\u304f\u5897\u6b96\u3067\u304d\u306a\u3044\u305f\u3081\u3001HuH-7\u7d30\u80de\u682a\u304c\u306a\u3051\u308c\u3070\u3001\u3044\u307e\u3060\u306b\u3001HCV\u306b\u5bfe\u3059\u308b\u85ac\u5264\u306f\u958b\u767a\u3055\u308c\u3066\u3044\u306a\u304b\u3063\u305f\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<hr>\n<div class=\"row\">\n<div class=\"col-sm-8\">\n<p>\u5f53\u5206\u91ce\u3067\u306f\u5ca1\u5c71\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u5168\u9577HCV (\u907a\u4f1d\u5b50\u578b1b, O\u682a)\u306b\u85ac\u5264\u8010\u6027\u907a\u4f1d\u5b50\u3068Renilla luciferase\u3092\u7d44\u307f\u8fbc\u3093\u3060\u5168\u9577HCV\u30ec\u30dd\u30fc\u30bf\u30fc\u30b7\u30b9\u30c6\u30e0\uff08OR6\uff09\u3092\u958b\u767a\u3057\u307e\u3057\u305f (\u56f3\uff11)\u3002OR6\u30a2\u30c3\u30bb\u30a4\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\u3053\u308c\u307e\u3067\u306b\u3001\u30b9\u30bf\u30c1\u30f3\u5264\uff08\u9ad8\u8102\u8840\u75c7\u6cbb\u7642\u5264\uff09\u3001\u30c6\u30d7\u30ec\u30ce\u30f3\uff08\u80c3\u85ac\uff09\u30015-HETE (\u30a2\u30e9\u30ad\u30c9\u30f3\u9178\u4ee3\u8b1d\u7523\u7269)\u3001N251\uff08\u6297\u30de\u30e9\u30ea\u30a2\u5264\uff09\u306a\u3069\u306e\u6297HCV\u6d3b\u6027\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001OR6\u30a2\u30c3\u30bb\u30a4\u30b7\u30b9\u30c6\u30e0\u306f\u56fd\u5185\u5916\u306e\u591a\u6570\u306e\u7814\u7a76\u65bd\u8a2d\u306b\u63d0\u4f9b\u5b9f\u7e3e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/p><\/div>\n<div class=\"col-sm-4\">\n<p><img decoding=\"async\" src=\"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/~bit\/wpowp-content\/themes\/ccvd_organic\/images\/contents\/research\/c\/research-hcv01.gif\" alt=\"\u56f31 \u85ac\u5264\u8010\u6027HCV RNA\u8907\u88fd\u7d30\u80de\u306e\u4f5c\u6210\u6cd5\"><\/p>\n<\/p><\/div>\n<\/div>\n<hr>\n<p>\u307e\u305f\u3001\u5ca1\u5c71\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3067HuH-7\u4ee5\u5916\u306b\u3001HCV\u306e\u5897\u6b96\u304c\u53ef\u80fd\u306a\u7d30\u80de\u682a\u3067\u3042\u308b\u3001\u30d2\u30c8\u809d\u304c\u3093\u7d30\u80de\u682a\u7531\u6765\u306eLi23\u3092\u7528\u3044\u3066\u3001\u5168\u9577HCV\u30ec\u30dd\u30fc\u30bf\u30fc\u30b7\u30b9\u30c6\u30e0\uff08ORL8\uff09\u3092\u958b\u767a\u81f4\u3057\u307e\u3057\u305f (\u56f3\uff12)\u3002ORL8\u30a2\u30c3\u30bb\u30a4\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u308b\u3068\u3001HuH-7\u3067\u306f\u4f4e\u611f\u53d7\u6027\u3067\u3042\u3063\u305f\u3001\u30ea\u30d0\u30d3\u30ea\u30f3\u3001IFN-\u03bb\u3001\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u306a\u3069\u3082\u9ad8\u611f\u53d7\u6027\u3068\u306a\u308b\u305f\u3081\u306b\u3001\u6297HCV\u6d3b\u6027\u306e\u6a5f\u5e8f\u3092\u7814\u7a76\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u73fe\u5728\u30012\u7a2e\u985e\u306e\u7d30\u80de\u682a (HuH-7\u304a\u3088\u3073Li23)\u3068\uff13\u7a2e\u985e\u306eHCV\u682a (O\u30011B-4 \u304a\u3088\u3073KAH5)\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u8a08\uff16\u7a2e\u985e\u306e\u30a2\u30c3\u30bb\u30a4\u7cfb\u304c\u958b\u767a\u6e08\u307f\u3067\u3042\u308a\u3001\u7d30\u80de\u682a\u306e\u9055\u3044\u3084\u3001HCV\u682a\u306e\u9055\u3044\u306b\u3088\u308b\u304d\u3081\u7d30\u304b\u3044\u85ac\u5264\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u3067\u304d\u308b\u4f53\u5236\u306b\u306a\u308a\u307e\u3057\u305f (\u56f3\uff13\u3001\u56f3\uff14)\u3002<\/p>\n<div class=\"row mg-bo-md mg-to-md\">\n<div class=\"col-sm-4\">\n<p><img decoding=\"async\" src=\"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/~bit\/wpowp-content\/themes\/ccvd_organic\/images\/contents\/research\/c\/research-hcv02.gif\" alt=\"\u56f32 2\u7a2e\u985e\u306e\u809d\u7d30\u80de\u682a\u306e\u6bd4\u8f03\"><\/p>\n<\/p><\/div>\n<div class=\"col-sm-4\">\n<p><img decoding=\"async\" src=\"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/~bit\/wpowp-content\/themes\/ccvd_organic\/images\/contents\/research\/c\/research-hcv03.gif\" alt=\"\u56f33 \u809d\u7d30\u80de\u304a\u3088\u3073\u30a6\u30a4\u30eb\u30b9\u682a\u306e\u80cc\u666f\"><\/p>\n<\/p><\/div>\n<div class=\"col-sm-4\">\n<p><img decoding=\"async\" src=\"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/~bit\/wpowp-content\/themes\/ccvd_organic\/images\/contents\/research\/c\/research-hcv04.gif\" alt=\"\u56f34 6\u7a2e\u985e\u306eHCV\u30ec\u30dd\u30fc\u30bf\u30fc\u30a2\u30c3\u30bb\u30a4\u7cfb\u306e\u85ac\u5264\u611f\u53d7\u6027\"><\/p>\n<\/p><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>C\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9 HCV\u57f9\u990a\u7d30\u80de\u7cfb\u306e\u958b\u767a \u6297\u30a6\u30a4\u30eb\u30b9\u5264\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306b\u306f\uff12\u3064\u306e\u3053\u3068\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\uff11\u3064\u76ee\u306f\u3001\u85ac\u5264\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3067\u3001\uff12\u3064\u76ee\u306f\u3001\u85ac\u5264\u306e\u30a2\u30c3\u30bb\u30a4\u306e\u305f\u3081\u306e\u57f9\u990a\u7d30\u80de\u3067\u3059\u3002\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u3064\u3044\u3066\u306f\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u304c\u552f\u4e00\u306e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":21,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-71","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/pages\/71","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/comments?post=71"}],"version-history":[{"count":2,"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/pages\/71\/revisions"}],"predecessor-version":[{"id":78,"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/pages\/71\/revisions\/78"}],"up":[{"embeddable":true,"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/pages\/21"}],"wp:attachment":[{"href":"https:\/\/ccvd.kufm.kagoshima-u.ac.jp\/bit\/wp-json\/wp\/v2\/media?parent=71"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}